Trophic Regulation of the Basal Ganglia
Editorial Reviews
Book Description
Since 1940 brain and pituitary extracts have been known to be capable of stimulating the proliferation of cultured fibroblasts. In 1974, one of these substances was partially purified and named FGF; later it was realised there exists a family of fibroblast growth factors, of which the best characterised are the FGF-1 and FGF-2 (aFGF, bFGF). More recent work has shown that FGFs have many actions and that they are active not only on fibroblasts, but also on a wide range of cell types including those of the central nervous system. This volume represents the state-of-the-art of our understanding of aFGF and bFGF in the basal ganglia. Thus, the localisation of those growth factors, the control mechanisms of their expression, and their trophic actions are analysed in relation to nerve cell survival as well as to the neurodegenerative diseases affecting the basal ganglia. Some of the most advanced research on degenerative and regenerative features of
Book Info
Karolinska Institute, Stockholm,Sweden. WennerGren International Series, Volume 62. Advanced research on growth factors in the basal ganglia, for neuroscientists and neurologists. Includes research on the degenerative and regenerative features of the basal ganglia. 25 contributors.
Trophic Regulation of the Basal Ganglia,K. Fuxe,Luigi F. Agnati,B. Bjelke,D. Ottoson,Elsevier Science Pub Co,0080422764,Basal ganglia,Congresses,Fibroblast growth factors,Human Nervous System,Medical / Nursing,Nerve growth factor,Neuroscience,Physiology,Reference
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